![]() ![]() There were no significant changes in PaO2, oxygen consumption, systemic vascular resistance, and cardiac output throughout the experiments.Ī gradual increase in artificial deadspace ventilation produces a state of deliberate hypercapnia. The systemic pH was decreased from a mean baseline value of 7.45 to 7.39, 7.28, 7.20, and 7.11, respectively. 05) increases of 23%, 32%, 45%, and 46% in the mean pulmonary vascular resistance values, and 6%, 16%, 23%, and 23% in the mean pulmonary arterial pressure, respectively. These increases in PaCO2 were associated with significant (p <. Increased artificial deadspace produced a significant (p <. ![]() Data were indexed to the animal's weight (in kg). Hemodynamic performance was evaluated at baseline and after 45 mL (3 to 4 mL/kg), 90 mL (6 to 8 mL/kg), 135 mL (9 to 11 mL/kg), and 180 mL (12 to 15 mL/kg) of added deadspace. The artificial deadspace was increased every 30 mins, by connecting 45-mL (3- to 4-mL/kg) corrugated tube segments until a total deadspace volume of 180 mL was added. The animals' lungs were ventilated with an FIO2 of 1.0, and a stable state of eucapnia was achieved and maintained for 30 mins. Systemic blood pressure was measured with use of a femoral arterial catheter. Prospective study, with each animal used as its own control.Ī quadrilumen thermodilution pulmonary artery catheter was placed in minipigs via the internal jugular vein. To develop a simple method in an animal model to achieve deliberate hypercapnia, which can be used easily and safely to regulate the pulmonary vascular resistance without changing mean airway pressure and compromising oxygenation. ![]()
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